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Resources » Paper

Nass R et al. (2003) Annu Rev Pharmacol Toxicol "The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration."

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  • Comments on Nass R et al. (2003) Annu Rev Pharmacol Toxicol "The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration." (0)

  • Overview

    PMID:
    12415122
    DOI:
    10.1146/annurev.pharmtox.43.100901.135934
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00005734

    Nass R, & Blakely RD (2003). The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration. Annu Rev Pharmacol Toxicol, 43, 521-44. doi:10.1146/annurev.pharmtox.43.100901.135934

    The neurotransmitter dopamine (DA) plays a central role in the coordination of movement, attention, and the recognition of reward. Loss of DA from the basal ganglia, as a consequence of degeneration of neurons in the substantia nigra, triggers postural instability and Parkinson's disease (PD). DA transporters (DATs) regulate synaptic DA availability and provide a conduit for the uptake of DA mimetic neurotoxins, which can be used to evoke neuronal death and Parkinson-like syndrome. Recently, we have explored the sensitivity of DA neurons in the nematode Caenorhabditis elegans to the Parkinsonian-inducing neurotoxin 6-hydroxydopamine (6-OHDA) and found striking similarities, including DAT dependence, to neurodegeneration observed in mammalian models. In this review, we present our findings in the context of molecular and behavioral dimensions of DA signaling in C. elegans with an eye toward opportunities for uncovering DAT mutants, DAT regulators, and components of toxin-mediated


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